FITC - anti mouse CD86 - Clone G1-1
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產(chǎn)品名稱: FITC - anti mouse CD86 - Clone G1-1
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FITC - anti mouse CD86 - Clone G1-1
FITC - anti mouse CD86 - Clone G1-1
的詳細介紹
FITC
- anti Mouse
CD86 - G1-1
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The minimum purchase order quantity for the product is 1
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The minimum purchase order quantity for the product is 1
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The minimum purchase order quantity for the product is 1
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G1-1
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Rat IgG2a
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Flow Cytometry
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FITC
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0.5 mg/ml
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Mouse (CBA/Ca) LPS-activated splenic B Cells
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Mouse
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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CD86, clone GL-1, is a mAb intended for RUO in the identification of cells that express CD86. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
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Liquid
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Store in the dark at 2-8 °C
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CD86 is a costimulatory molecule expressed on a broad spectrum of leukocytes, including B lymph ocytes, T lymph ocytes, thioglycollate-induced peritoneal macrophages, dendritic cells and astrocytes. CD86 is expressed at low levels by freshly explanted peripheral B and T cells, and its expression is substantially increased by a variety of T cell- and B cell-specific stimuli with a peak expression after 18-42 hours of culture. In contrast to most naive CD4+ T cells, memory CD4+ T cells express B7-2, both at the mRNA and protein level. CD86, a ligand for CD28 and CD152 (CTLA-4), is one of the accessory molecules that plays an important role in T cell-B cell costimulatory interactions. It has been shown to be involved in immunoglobulin class-switching and triggering of mouse NK cell-mediated cytotoxicity. CD80 (B7-1) is an alternate ligand for CD28 and CD152 (CTLA-4). GL1 antibody reportedly blocks MLR and stimulation of T cells by natural antigen-presenting cells. In addition, a mixture of anti-B7-1 and anti B7-2 (GL1) mAbs reportedly inhibits the in vitro interaction of CTLA-4 with its ligand and the in vivo priming of cytotoxic T lymph ocytes.
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B7-2, B70, Ly-58
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12524
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80 kD
