PE - anti mouse CD19 - Clone 1D3
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產(chǎn)品名稱: PE - anti mouse CD19 - Clone 1D3
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PE - anti mouse CD19 - Clone 1D3
PE - anti mouse CD19 - Clone 1D3
的詳細(xì)介紹
PE
- anti Mouse
CD19 - 1D3
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The minimum purchase order quantity for the product is 1
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The minimum purchase order quantity for the product is 1
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1D3
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IgG2a
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Flow Cytometry
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PE
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0.2 mg/ml
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Mouse CD19-transfected cell line
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Mouse
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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Liquid
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Store in the dark at 2-8 °C
CD19, a 95-kDa transmembrance glycoprotein, is a member of the immunoglobulin superfamily and is expressed throughout B-lymph ocyte development from the pro-B cell throughthe mature B-cell stages. Terminally differentiated plasma cells do not express CD19. On the surface of mature B cells, the CD19 molecule associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to promote cellular activation. Studies with CD19-deficient mice have suggested that the level of CD19 expression affects the generation and maturation of B cells in the bone marrow and periphery. B-1 lineage B cells, also known as CD5+ B cells, are drastically reduced or absent in CD19-deficient mice. Increased levels of CD19 expression correlate with increased frequencies of peritonal and splenic B-1 cells and reduced numbers of conventional B lymph ocytes in the periphery. CD19 participates in B-lymph ocyte development, B-cell activation, maturation of memory B cells and regulation of tolerance. CD19 has also been detected on peritoneal mast cells, co-localized with CD21/CD35, and it is proposed to play a role in complement-mediated mast-cell activation.
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B4
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95 kD
