PURE - anti mouse CD45.1 - Clone A20
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產(chǎn)品名稱: PURE - anti mouse CD45.1 - Clone A20
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PURE - anti mouse CD45.1 - Clone A20
PURE - anti mouse CD45.1 - Clone A20
的詳細(xì)介紹
PURE
- anti Mouse
CD45.1 - A20
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The minimum purchase order quantity for the product is 1
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A20
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Mouse IgG2a
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Flow Cytometry
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PURE
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0.5 mg/ml
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SJL mouse thymocytes and splenocytes
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Mouse
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The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
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RUO
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CD45.1, clone A20, is a mAb intended for RUO in the identification of cells that express CD45.2. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 μg/106 cells.
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Liquid
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Store in the dark at 2-8 °C
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CD45 (Lukocyte Common Antigen) is foundon all leukocytes of mouse strains expressing the CD45.1 alloantigen (eg, RIII, SJL/J, STS/A, DA). This alloantigen was originally named Ly-5.2, and this was the designation at the time that the antibody was characterized. The designation was later changed from Ly-5.2 to Ly-5.1 to conform with the convention that the .2 alloantigen designations be assigned to the C57BL/6 strain. mAb A20 has been reported not to react with leukocytes of most other mouse strains, which express the CD45.2 alloantigen. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C,respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. The A20 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.1 alloantigen, to antigens and LPS.
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Ly-5; Lyt4; CD45R; LCA; Ptprc; Protein tyrosine phosphatase receptor type C
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180-240 kD
