CD59 Molecule Complement Regulatory Protein, CD59 Antigen P18-20, CD59 Glycoprotein, Surface Anitgen Recognized By Monoclonal
Antibody 16.3A5, Membrane Attack Complex (MAC) Inhibition Factor, Lymphocytic Antigen CD59/MEM43, Human Leukocyte Antigen MIC11, Membrane Attack Complex Inhibition Factor, 20 KDa Homologous Restriction Factor, Membrane Inhibitor Of Reactive Lysis, MAC-Inhibitory Protein, T Cell-Activating Protein, Ly-6-Like Protein, Protectin, MIC11, MSK21, MEM43, MIN1/2/3, MIRL, MAC-IP, MACIF, HRF-20, G344, EJ16/30/32, 1F5.
CD59 is a cell surface glycoprotein which regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. CD59 is an effective inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the compilation of this complex, thus inhibiting the incorporation of multiple copies of C9 into the complex, which is essential for osmolytic pore formation. In addition, CD59 has a role in signal transduction pathways in the activation of T cells. CD59 gene mutations cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction.
CD59 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 100 amino acids (26-102) and having a molecular mass of 11.3kDa.
CD59 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Escherichia Coli.
Sterile filtered colorless solution.
The CD59 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol.
Store at 4°C if entire vial will be used within 2-4 weeks.?
Store, frozen at -20°C for longer periods of time.?
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Greater than 85% as determined by SDS-PAGE.
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
