Cadherin-5,
Vascular endothelial cadherin, VE-cadherin, CD144, Cdh5.
Cadherin-5, also known as CDH5 is a classical cadherin which belongs to
the cadherin superfamily. The CDH5
is located in a six-cadherin
cluster in a region on the long arm of chromosome 16 which is involved in loss
of
heterozygosity events in breast as well as prostate cancer.
CDH5 is a calcium-dependent cell-cell
adhesion glycoprotein
composed of five extracellular cadherin repeats, a transmembrane region and a
highly
conserved cytoplasmic tail. Furthermore, CDH5 functions
as a classic cadherin by passing on to cells the ability to adhere in a
homophilic manner, CDH5?
plays a significant role in endothelial cell
biology through control of
the cohesion as well as organization of the intercellular junctions
.CDH5 produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 583 amino acids (25-599a.a.) and having a molecular mass of 66.2kDa. (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).
CDH5 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sterile
filtered colorless solution.
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Greater
than 90.0% as determined by SDS-PAGE.
GPNFPQIDTP NMLPAHHRQK RDWIWNQMHI DEEKNESLPH
YVGKIKSNVN RQNAKYVLQG EFAGKIFGVD ANTGNVLAYE RLDREKVSEY FLTALIVDKN TNKNLEQPSS
FTVKVHDIND NWPVFSHQVF NASVPEMSAI GTSVIRVTAV DADDPTVAGH ATVLYQIVKG NEYFSIDNSG
LIFTKIKNLD REKQAEYKIV VETQDALGLR GESGTATVMI RLEDINDNFP VFTQSTYTFS VPEDIRVGKP
LGFLTVVDPD EPQNRMTKYS IMQGEYRDTF TIETDPKRNE GIIKPTKSLD YEVIQQYTFY IEATDPTIRY
EYLSSTSGKN KAMVTINVLD VDEPPVFQRH FYHFKLPENQ KKPLIGTVVA KDPDKAQRSI GYSIRKTSDR
GQFFRITKQG NIYNEKELDR ETYAWYNLTV EANELDSRGN PVGKESIVQV YIEVLDENDN PPEFAQPYEP
KVCENAAQGK LVVQISATDK DVVPVNPKFK FALKNEDSNF TLINNHDNTA NITVKYGQFN REHAKFHYLP
VLISDNGVPS LTGTSTLTVG VCKCNEQGEF TFCEEMAAQA GVSIQLEHHH HHH.
ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
