ER-alpha

Mouse anti-Estrogen Receptor Alpha (human and mouse).

Estrogen receptors ? (ER?, ER; NR3A1) is a member of the steroid hormone receptor family. ?ER? is a ligand-activated transcription factor. ?ER? contain DNA binding and ligand binding domains. ? ER? is expressed in a wide variety of tissues, including ovary, uterus, breast, prostate, testis, epididymis, bones, bladder, kidney, heart, vessel wall, pituitary gland and hypothalamus. ER plays a variety of important roles in the maintenance of the reproductive, cardiovascular, musculoskeletal and central nervous systems. ? The natural ligand for ER is 17?-estradiol, the classical estrogenic compound. ?The binding of estrogen to ER induces a conformational change and triggers a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes.?

Recombinant human ER-alpha.

Mouse IgG.

Protein A.

Lyophilized: store at 4°C. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

Reconstitute with of H2O. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Western Blot, Immunofluorescent Staining, Immunohistochemistry, flow cytometry, immunoprecipitation.

This antibody is only available as purified antibody.

Prospec's products are furnished for LABORATORY ESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.