Thrombin-like enzyme batroxobin, EC 3.4.21.74, BX, Bothrops atrox serine proteinase, Venombin-A, Defibrase, Reptilase, Batroxobin.

Batroxobin is a serin protease that reduces fibronogen levels and is originally extracted from snake venom of Bothrops Atrox. Batroxobin is used in defibrinogenation and thrombolysis and also has an effect on c-fos gene and growth factor.
Batroxobin can efficiently restrain proliferation of VSMCs, by blocking the release and uptake of Ca2+, thus influencing [Ca2+]i.
Batroxobin converts fibrinogen to fibrin through the restricted release of fibrinopeptide-A from fibrinogen to promote blood to clot. Unlike thrombin, it is not affected by heparin and hirudin.

Batroxobin, isolated from Bothrops atrox snake venom, has an Mw of approximately 43kDa.

Sterile Filtered white lyophilized powder.

The Batroxobin protein was lyophilized from a concentrated (1mg/ml) solution with no additives.

It is recommended to reconstitute the lyophilized Batroxobin in sterile 18M-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.

Batroxobin although stable at room temperature for 3 weeks, should be stored below -18°C. Upon reconstitution?Batroxobin?should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Please prevent freeze-thaw cycles.

100BU [Batroxobin Units]=1mg.

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